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Merck

16772

Sigma-Aldrich

溴化氰

≥98.5% (RT)

别名:

氰化溴

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About This Item

线性分子式:
BrCN
CAS号:
分子量:
105.92
Beilstein:
1697296
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

蒸汽密度

3.65 (vs air)

品質等級

蒸汽壓力

100 mmHg ( 22.6 °C)

化驗

≥98.5% (RT)

形狀

crystals

bp

61-62 °C (lit.)

mp

50-53 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

BrC#N

InChI

1S/CBrN/c2-1-3

InChI 密鑰

ATDGTVJJHBUTRL-UHFFFAOYSA-N

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應用

  • Cyanogen bromide is widely used in protein immobilization and cleavage.
  • Under von Braun reaction conditions, CNBr reacts with tertiary amines to yield respective organocyanamides.
  • It can also be used to synthesize organic intermediates like cyanuric bromide, derivatives of urea, guanidine, creatine, aryl nitriles, and a variety of heterocyclic compounds.

其他說明

用于选择性断裂肽键(如蛋氨酸)的试剂

訊號詞

Danger

危險分類

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B

安全危害

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

>149.0 °F - closed cup

閃點(°C)

> 65 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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von Braun reaction.
Name Reactions, 562-563 (2009)
The von Braun Reaction Applied to Azetidines.
Wright K, et al.
European Journal of Organic Chemistry, 2017(47), 195-7201 (2017)
Synthesis of hindered chiral guanidine bases starting from (S)-(N, N-dialkyl-aminomethyl) pyrrolidines and BrCN.
Kohn U, et al.
Tetrahedron Asymmetry, 17(5), 811-818 (2006)
Straightforward Conversion of Alcohols into Nitriles.
Tarrade-Matha A, et al.
Synthetic Communications, 40(11), 1646-1649 (2010)
New Protocol for the Synthesis of 2-Alkanoyl-and 2-Aryloyl-5, 5-dimethylcyclohexane-1, 3-diones by the Reaction of Dimedone with Various Aldehydes and Cyanogen Bromide in the Presence of Triethylamine.
Kashani E, et al.
Synthesis, 48(13), 2079-2084 (2016)

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