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法律遵循
suitable for FDA C-010.02
化驗
97%
形狀
liquid
密度
0.92 g/mL at 25 °C (lit.)
儲存溫度
2-8°C
SMILES 字串
CN1CCC(=O)CC1
InChI
1S/C6H11NO/c1-7-4-2-6(8)3-5-7/h2-5H2,1H3
InChI 密鑰
HUUPVABNAQUEJW-UHFFFAOYSA-N
應用
N-甲基-4-哌啶酮可作为反应物，用于制备：
- 螺环哌啶环，通过与丙二腈与亲电试剂或Michael受体反应。
- (3E,5E)-1-甲基-3,5-双(苯亚甲基)-4-哌啶酮，通过Michael加成反应与苯甲醛反应，然后发生O-环化/消除连续反应。
- N,N′-Dimethylbispidinone，使用双曼尼希冷凝法。
其他客户在看
Bin-Rong Yao et al.
European journal of medicinal chemistry, 167, 187-199 (2019-02-17)
To get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity, a series of dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, 25-82) were designed and synthesized. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity
Analogs of sparteine. I. A reexamination of the reaction of n-methyl-4-piperidone with formaldehyde and methylamine. A revised synthesis of n,n'-dimethylbispidinone.
E E Smissman et al.
The Journal of organic chemistry, 40(2), 251-252 (1975-01-24)
Chang-Ming Su et al.
Journal of enzyme inhibition and medicinal chemistry, 34(1), 1287-1297 (2019-07-11)
Inhibition of NF-κB signalling has been demonstrated as a therapeutic option in treating inflammatory diseases and cancers. Herein, we synthesized novel dissymmetric 3,5-bis(arylidene)-4-piperidones (BAPs, 83-102) and characterized fully. MTT and ELISA assay were performed to screen the anti-hepatoma and anti-inflammation
Ning Li et al.
European journal of medicinal chemistry, 155, 531-544 (2018-06-18)
Ten novel symmetric 3,5-bis(arylidene)-4-piperidone derivatives (BAPs, 1-10) and fourteen dissymmetric BAPs (11-24) were synthesized and evaluated the cytotoxicity. All of the compounds have been screened for their anti-inflammatory activity characterized by evaluating their inhibitory effects on LPS-induced IL-6, TNF-α secretion.
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