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Merck

PRKCG

protein kinase C, gamma

别名:
PKC-gamma, PKCC, PKCG, SCA14
物种:
UniProtKB ID:
基因ID:
  • Human(5582) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
  • Mouse(18752) protein kinase C, gamma
  • Rat(24681) protein kinase C, gamma
  • Zebrafish(100003514) protein kinase C, gamma
  • dog(484316) protein kinase C, gamma
  • Horse(100062549) protein kinase C, gamma
  • domestic cat(101082196) protein kinase C, gamma
  • domestic guinea pig(100733947) protein kinase C, gamma
  • Domestic Rabbit(100009102) protein kinase C, gamma
  • naked mole-rat(101698346) protein kinase C, gamma
  • cow(282002) protein kinase C, gamma
  • sheep(101116423) protein kinase C, gamma

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Small Molecule - Agonist

货号
说明
物种
油酸, ≥99% (GC),
物种
human

Antibodies

货号
说明
物种反应性
应用
Anti-PKC gamma Antibody, clone 5F2X3, Rabbit Monoclonal, ,
物种反应性
mouse, rat
应用
western blot
Anti-PKCγ (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human, mouse
应用
ELISA
western blot
Anti-PRKCG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-PRKCG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
单克隆抗 蛋白激酶 C (PKC) 小鼠抗, clone MC5, ascites fluid,
物种反应性
bovine, human, mouse, rat
应用
immunohistochemistry
immunoprecipitation (IP)

microarray

western blot

Small Molecule - Inhibitor

货号
说明
物种
H-7 dihydrochloride, ≥98% (HPLC),
物种
human
他莫昔芬 柠檬酸盐, ≥99%,
物种
human
油酸, ≥99% (GC),
物种
human
UCN-01, ≥97% (HPLC), powder,
物种
human
GSK690693, ≥98% (HPLC),
物种
human

Proteins

货号
说明
物种
PKCγ, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human PRKCG,
物种
human