LDLR
low density lipoprotein receptor
别名:
FH, FHC, LDLCQ2
物种:
Human LDLR (3949), Mouse Ldlr (16835), Rat Ldlr (300438), Zebrafish ldlr (387529), dog LDLR (100683160), chicken LDLR (395103), domestic cat LDLR (101080362), cow LDLR (281276), Domestic Rabbit LDLR (100009086), domestic guinea pig Ldlr (100724238)
UniProtKB ID:
基因ID:
- Human(3949) Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- Mouse(16835) low density lipoprotein receptor
- Rat(300438) low density lipoprotein receptor
- Zebrafish(387529) low density lipoprotein receptor
- dog(100683160) low density lipoprotein receptor
- chicken(395103) low density lipoprotein receptor
- domestic cat(101080362) low density lipoprotein receptor
- cow(281276) low density lipoprotein receptor
- Domestic Rabbit(100009086) low density lipoprotein receptor
- domestic guinea pig(100724238) low density lipoprotein receptor
- naked mole-rat(101703463) low density lipoprotein receptor
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ELISA
货号
说明
物种
Antibodies
货号
说明
物种反应性
应用
Anti-LDLR antibody produced in rabbit, Ab1, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-LDL Receptor Antibody, clone 2N19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, rat
应用
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-LDLR antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
western blot
Anti-LDL-R antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-LDL Receptor (LDLR) Antibody, clone 10K4L8, Rabbit Monoclonal, ,
物种反应性
human, rat
应用
immunofluorescence
western blot
western blot