SML1277

Geldanamycin-FITC

≥98% (HPLC), from Streptomyces hygroscopicus

• Synonym(s): Geldanamycin, fluorescein isothiocyanate labeled
• Empirical Formula (Hill Notation): C₅₅H₆₃N₅O₁₃S
• Molecular Weight: 1034.18
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• biological source: Streptomyces hygroscopicus
• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: yellow to yellow-orange
• solubility: DMSO: soluble 5 mg/mL
• antibiotic activity spectrum: neoplastics
• Mode of action: enzyme | inhibits
• storage temp.: −20°C

Description

General description

Chemical structure: benzenoid

Biochem/physiol Actions

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable