SML1121

SB743921 hydrochloride

≥98% (HPLC)

• Synonym(s): N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride
• Empirical Formula (Hill Notation): C₃₁H₃₃ClN₂O₃ · HCl
• CAS Number: 940929-33-9
• Molecular Weight: 553.52
• MDL number: MFCD18385010
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825661
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CC(C)[C@@H](N(CCCN)C(C1=CC=C(C)C=C1)=O)C2=C(CC3=CC=CC=C3)C(C4=C(O2)C=C(Cl)C=C4)=O.Cl
• InChI: 1S/C31H33ClN2O3.ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30;/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3;1H/t28-;/m1./s1
• InChI key: MLMZVWABFOLFGV-LNLSOMNWSA-N

Description

Biochem/physiol Actions

SB743921 is an inhibitor of kinesin spindle protein (KSP) with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4, and CENP-E.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable