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Key Documents

SML0927

Sigma-Aldrich

Diapocynin

≥98% (HPLC)

Synonym(s):

1,1′-(6,6′-Dihydroxy-5,5′-dimethoxy[1,1′-biphenyl]-3,3′-diyl)bis-ethanone, 4′,4′′′-Dihydroxy-5′,5′′′-dimethoxy-3′,3′′′-biacetophenone (8CI), Dehydrodiacetovanillone

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About This Item

Empirical Formula (Hill Notation):
C18H18O6
CAS Number:
Molecular Weight:
330.33
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

Biochem/physiol Actions

Diapocynin is a covalent dimer of apocynin, and a functional metabolite of the same. It is generated by neutrophil activation via myeloperoxidase-mediated oxidation. Studies show that diapocynin has greater neuroprotection compared to apocynin.
Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent. Diapocynin attenuates oxidative damage and neuroinflammatory responses in animal model of Parkinson′s disease. Diapocynin reverses deficient motor coordination in LRRK2R1441Gtg mice of PD.

Pictograms

Environment

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice
Trumbull KA, et al.
Neurobiology of Disease, 45(1), 137-144 (2012)
Sclerosis: New Insights for the Healthcare Professional, 25-25 (2012)

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