SML0063

Q-VD-OPh hydrate

≥95% (HPLC), powder, pan-caspase inhibitor

• Synonym(s): 5-(2,6-Difluorophenoxy)-3-[[3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-pentanoic acid hydrate
• Empirical Formula (Hill Notation): C₂₆H₂₅F₂N₃O₆ · xH₂O
• CAS Number: 1435786-01-8
• Molecular Weight: 513.49 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825128
• NACRES: NA.77

Properties

• Product Name: Q-VD-OPh hydrate, ≥95% (HPLC)
• Assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to light brown
• solubility: DMSO: ≥14 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: O=C(NC(C(C)C)C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(O)=O)=O)C2=NC3=CC=CC=C3C=C2.[H]O[H]
• InChI: 1S/C26H25F2N3O6.H2O/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28;/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34);1H2/t20-,23-;/m0./s1
• InChI key: ONOTWLLTFZMERH-WCRWPNQISA-N

Description

Application

Q-VD-OPh hydrate has been used:

• as a pan-caspase inhibitor to prevent cell death in urothelial carcinoma cells (UCC)
• to induce canonical caspase-dependent apoptosis in UC cells
• to block caspase-3 and Poly (ADP-ribose) polymerase-1 (PARP-1)
• to study the protective role of EspZ effector protein against apoptosis and necrosis in human epithelial cells

Biochem/physiol Actions

Q-VD-OPh is a potent pan-caspase inhibitor that protects cells from capsase-dependent apoptosis. Q-VD-OPh has superior aqueous stability, cell permeability, and efficacy than FMK-based caspase inhibitors and displays no cytotoxic effects alone.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable