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Key Documents

SAB4300613

Sigma-Aldrich

Anti-Cry1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-AU020726 antibody produced in rabbit, Anti-AU021000 antibody produced in rabbit, Anti-Phll1 antibody produced in rabbit, Anti-cryptochrome 1 (photolyase-like) antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~60 kDa

species reactivity

mouse

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(S-Q-G-S-G)

NCBI accession no.

NP_031797.1

UniProt accession no.

P97784

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cry1(12952)

General description

Cry1 (cryptochrome circadian regulator 1) belongs to the cryptochrome family. It is located on human chromosome 12q23.

Immunogen

Peptide sequence around aa. 551-555 (S-Q-G-S-G), according to the protein Cry1.

Biochem/physiol Actions

Cry1 (cryptochrome circadian regulator 1) controls gluconeogenesis. It induces tumor development and multiplication. Overexpression of Cry1 results in tumor progression and poor clinical indications in individuals with colorectal Cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer
Yu H, et al.
PLoS ONE (2013)
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American
Dashti HS, et al.
Chronobiology International, 31(5), 660-667 (2014)
Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder
Soria V, et al.
Neuropsychopharmacology, 35(6), 1279-1289 (2010)

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