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Key Documents

SAB4300609

Sigma-Aldrich

Anti-FLT4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-FLT41 antibody produced in rabbit, Anti-LMPH1A antibody produced in rabbit, Anti-PCL antibody produced in rabbit, Anti-VEGFR3 antibody produced in rabbit, Anti-fms-related tyrosine kinase 4 antibody produced in rabbit

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About This Item

MDL number:
MFCD03097363
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~160 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(L-A-S-E-E)

NCBI accession no.

NP_002011.2

UniProt accession no.

P35916

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FLT4(2324)

General description

Fms related tyrosine kinase 4 (FLT4) is also known as vascular endothelial growth factor receptor 3 (VEGFR3). It is expressed in the blood and lymphatic endothelial cells during early development. The gene encoding FLT4 is localized on human chromosome 5q35.3.

Immunogen

Peptide sequence around aa. 1279-1283 (L-A-S-E-E), according to the protein FLT4.

Application

Anti-FLT4 antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

Fms related tyrosine kinase 4 (FLT4) has a role in lymphangiogenesis and angiogenesis. It acts as an activator in signaling pathways. Mutations in the gene encoding FLT4 have been linked to Milroy disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Receptor for VEGFC. Has a tyrosine-protein kinase activity.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions
Guo, Tianhua, et al
Genes Chromosomes Cancer (2011)
A novel FLT4 Gene mutation and MR lymphangiography in a Chinese family with Milroy disease
Liu, N., et al.
Lymphology, 93-6 (2015)
Molecular controls of lymphatic VEGFR3 signaling
Deng, Yong et al.
Atherosclerosis: Treatment and Prevention (2014)
Two anti-angiogenic TKI-PET tracers, [11C]axitinib and [11C]nintedanib: Radiosynthesis, in vivo metabolism and initial biodistribution studies in rodents
Paul S, et al.
Nuclear Medicine and Biology null
Silvia D'Alessio et al.
The Journal of clinical investigation, 124(9), 3863-3878 (2014-08-12)
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) of unknown etiology that are associated with an aberrant mucosal immune response. Neoangiogenesis and vascular injury are observed in IBD along with increased lymphangiogenesis. While the pathogenic
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