SAB3500978
Anti-ACE2 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-ACEH
Sign Into View Organizational & Contract Pricing
All Photos(3)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ACE2(59272)
General description
Angiotensin-converting enzyme-2 (ACE2) gene is mapped to human chromosome Xp22.2. The gene codes for a membrane-associated and secreted enzyme. Ace 2 is a human homolog of angiotensin-converting enzyme (ACE) and is found mainly on endothelium. In humans, Ace2 is exclusively expressed in heart, kidney, and testis. The protein is characterized with an N-terminal PD and a C-terminal collectrin-like domain (CLD).
Immunogen
Antibody was raised against a synthetic peptide corresponding to amino acids near the N terminus of human ACE2.
Biochem/physiol Actions
Angiotensin-converting enzyme-2 (ACE2) aids in maturation of angiotensin (Ang) by converting Ang I to Ang1-9. It may also play a role in the local renin-angiotensin system (RAS) in heart and kidney. Ace 2 serves as a functional receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is responsible for causing coronavirus disease 2019 (COVID-19). Reduced expression of Ace 2 might cause cardiovascular diseases.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3500978.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodim azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
related product
Product No.
Description
Pricing
Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Jaśmina Bałaban et al.
Nanotechnology, science and applications, 16, 1-18 (2023-01-27)
The experiments aimed to document the presence of the ACE2 receptor on human muscle cells and the effects of the interaction of these cells with the spike protein of the SARS-CoV-2 virus in terms of induction of pro-inflammatory proteins, as
M Donoghue et al.
Circulation research, 87(5), E1-E9 (2000-09-02)
ACE2, the first known human homologue of angiotensin-converting enzyme (ACE), was identified from 5' sequencing of a human heart failure ventricle cDNA library. ACE2 has an apparent signal peptide, a single metalloprotease active site, and a transmembrane domain. The metalloprotease
S R Tipnis et al.
The Journal of biological chemistry, 275(43), 33238-33243 (2000-08-05)
A novel human zinc metalloprotease that has considerable homology to human angiotensin-converting enzyme (ACE) (40% identity and 61% similarity) has been identified. This metalloprotease (angiotensin-converting enzyme homolog (ACEH)) contains a single HEXXH zinc-binding domain and conserves other critical residues typical
Michael A Crackower et al.
Nature, 417(6891), 822-828 (2002-06-21)
Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. Here we show that angiotensin-converting enzyme 2 (ace2) maps to a defined quantitative trait locus (QTL) on the X chromosome in three different rat models
Wenhui Li et al.
Nature, 426(6965), 450-454 (2003-12-04)
Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target cells. Here we identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2), isolated from SARS coronavirus (SARS-CoV)-permissive
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service