SAB2702133

Monoclonal Anti-CEP164 antibody produced in mouse

• Synonym(s): Cep164 Antibody, Cep164 Antibody - Monoclonal Anti-CEP164 antibody produced in mouse, NPHP15
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 13; monoclonal
• form: liquid
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): immunocytochemistry: suitable; immunofluorescence: suitable; immunoprecipitation (IP): suitable; western blot: 1:500-1:3000
• isotype: IgG1
• UniProt accession no.: Q9UPV0
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CEP164(22897)

Description

General description

The centrosomal protein 164 (CEP164) is expressed at the distal ends of the mother centriole. This protein consists of an N-terminal WW domain and three coiled-coil regions. The CEP164 gene is located on the human chromosome at 11q23.3.

Immunogen

Human Cep164

Application

Monoclonal Anti-CEP164 antibody produced in mouse has been used in immunoblotting (5 μg/ml).

Biochem/physiol Actions

The centrosomal protein 164 (CEP164) plays an important role in the synthesis of the primary cilium. This protein interacts with several proteins during ciliogenesis such as Rabin-8, Tau tubulin kinase‐2 (TTBK2), coiled-coil domain containing 41 (CCDC41), and dishevelled (DVL). CEP164 protein is also involved in G2/M checkpoint and nuclear divisions. This protein is a key player in the DNA damage-activated ataxia telangiectasia mutated (ATM)/Rad3-related (ATR) signaling cascade since it is required for the proper phosphorylation of the histone family member X (H2AX), replication protein A (RPA), checkpoint kinase 1 and 2 (CHK1/2). Mutations in the CEP164 gene leads to a condition known as nephronophthisis (NPHP)‐related ciliopathies.

Features and Benefits

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Physical form

Phosphate-buffered saline, no preservative added.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable