SAB1401365

Anti-SLC14A1 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• Synonym(s): FLJ33745, FLJ41687, HUT11, HsT1341, JK, RACH1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, human
• technique(s): western blot: 1 μg/mL
• NCBI accession no.: BC050539
• UniProt accession no.: Q13336
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SLC14A1(6563)

Description

General description

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. (provided by RefSeq)

Immunogen

SLC14A1 (AAH50539.1, 1 a.a. ~ 389 a.a) full-length human protein.

Sequence
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSVLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFENIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL

Biochem/physiol Actions

SLC14A1 (solute carrier family 14 member 1) mediates the transport of urea across cell membrane and maintains its concentration in bladder urothelial cells. Variation or mutation in SLC14A1 is associated with the risk of bladder cancer and also with hypertension and metabolic syndrome. Thus, the gene serves as an important prognostic marker in the detection of urothelial carcinoma. SLC14A1 knockout promotes DNA damage and cell death in bladder urothelium. In human, silencing SLC14A1 gene accounts for Kidd blood type and therefore, the gene plays a role in transfusion medicine and organ transplantation.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable