Q111
(±)-Quinpirole dihydrochloride
powder
Synonym(s):
trans-(±)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline dihydrochloride, LY-141,865
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About This Item
Empirical Formula (Hill Notation):
C13H21N3 · 2HCl
CAS Number:
Molecular Weight:
292.25
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
form
powder
Quality Level
color
white
solubility
H2O: 28 mg/mL
storage temp.
−20°C
SMILES string
Cl.Cl.[H][C@]12CCCN(CCC)[C@]1([H])Cc3cn[nH]c3C2
InChI
1S/C13H21N3.2ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;;/h9-10,13H,2-8H2,1H3,(H,14,15);2*1H/t10-,13-;;/m1../s1
InChI key
GJIGRGIGKHPYTK-OWVUFADGSA-N
Gene Information
human ... DRD2(1813)
Biochem/physiol Actions
D2-like dopamine receptor agonist that possesses some activity at D3 sites.
Legal Information
Manufactured and sold with the permission of Eli Lilly and Company.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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D Eilam et al.
European journal of pharmacology, 161(2-3), 151-157 (1989-02-28)
The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of the drug. Results showed that the
Gunnar F Kwakye et al.
Neurotoxicology, 70, 48-61 (2018-11-07)
Huntington's disease (HD) is functionally linked to environmental factors including cigarette use and dyshomeostasis in the levels of metals. Interestingly, one of the most abundant heavy metals in cigarettes is cadmium (Cd), which also accumulates in the striatum and causes
Cristina Cariulo et al.
Biochemical and biophysical research communications, 521(3), 549-554 (2019-11-05)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of a CAG triplet repeat (encoding for a polyglutamine tract) within the first exon of the huntingtin gene. Expression of the mutant huntingtin (mHTT) protein can result in
L J Munro et al.
Brain research, 746(1-2), 231-238 (1997-01-23)
Dopamine (DA) D2 and gamma-aminobutyric acid (GABA)A somatodendritic receptors tonically inhibit mesolimbic projection neurons in the A10 DA cell grouping of the ventral tegmentum. In the present study we determined the contribution of the ventral tegmental area (VTA) to the
S Rosenzweig-Lipson et al.
Pharmacology, biochemistry, and behavior, 51(4), 843-848 (1995-08-01)
The present study investigated whether potassium channel blockade could modify the behavioral effects of the dopamine D2/D3 receptor agonist quinpirole in squirrel monkeys. The duration of immobility and/or unusual postures indicative of catalepsy-associated behavior or the duration of scratching, known
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