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Key Documents

N4912

Sigma-Aldrich

NMA-Gly-Cys-Gly-Val-Leu-Leu-Lys(dnp)-Arg-Arg-NH2 trifluoroacetate salt

≥95% (HPLC), solid

Synonym(s):

NMA-GCGVLLK(dnp)RR-NH2

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About This Item

Empirical Formula (Hill Notation):
C56H90N20O14S · xC2HF3O2
Molecular Weight:
1299.50 (free base basis)
MDL number:
MFCD08277027
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥95% (HPLC)

form

solid

storage condition

desiccated
protect from light
under inert gas

color

yellow

solubility

H2O: ≥0.5 mg/mL

shipped in

wet ice

storage temp.

−20°C

Amino Acid Sequence

Nme-Asp-Gly-Cys-Gly-Val-Leu-Leu-Lys-DNP-Arg-Arg-NH2

Biochem/physiol Actions

Notch 1 Peptide, fluorogenic

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Yoshihito Taniguchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(6), 4014-4019 (2002-03-14)
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called gamma-secretase

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