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Key Documents

AV35821

Sigma-Aldrich

Anti-ZIC2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-HPE5, Anti-Zic family member 2 (odd-paired homolog, Drosophila)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

mol wt

55 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_009060

UniProt accession no.

O95409

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ZIC2(7546)

Immunogen

Synthetic peptide directed towards the C terminal region of human ZIC2

Biochem/physiol Actions

ZIC2 is a C2H2-type zinc finger protein that functions as a repressor of transcription and regulates the tissue specific expression of dopamine receptor D1. Expression of ZIC2 is important for the development of nervous system and extension of neurites. ZIC2 inhibits the signaling mediated by Wnt/β-catenin during embryonic development.

Sequence

Synthetic peptide located within the following region: EPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGS

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Y Zhang et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 25(6), 538-541 (2013-02-19)
From a forward genetic screen in mice we isolated a novel Zic2 allele with abnormal aggregation of meconium in the gastrointestinal tract. Zic2(m1Nisw) mutant embryos show an increase in the number of enteric neurons in vivo and disorganization of the
Zhi-Hua Liu et al.
International journal of cancer, 147(2), 505-518 (2020-02-18)
Although early detection and systemic therapies have improved the diagnosis and clinical cure rate of breast cancer, breast cancer remains the most frequently occurring malignant cancer in women due to a lack of sufficiently effective treatments. Thus, to develop potential
Rasoul Pourebrahim et al.
The Journal of biological chemistry, 286(43), 37732-37740 (2011-09-13)
The Zic transcription factors play critical roles during embryonic development. Mutations in the ZIC2 gene are associated with human holoprosencephaly, but the etiology is still unclear. Here, we report a novel function for ZIC2 as a regulator of β-catenin·TCF4-mediated transcription.

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