A0788
3-Aminobenzamide
≥99% (TLC)
Synonym(s):
3-AB, 3-ABA
Sign Into View Organizational & Contract Pricing
All Photos(4)
About This Item
Linear Formula:
H2NC6H4CONH2
CAS Number:
Molecular Weight:
136.15
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Assay
≥99% (TLC)
form
powder
color
white to off-white
mp
115-116 °C (lit.)
solubility
ethanol: 50 mg/mL, clear, light yellow
DMSO: soluble
H2O: soluble (may require gentle heating)
storage temp.
room temp
SMILES string
NC(=O)c1cccc(N)c1
InChI
1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChI key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
Gene Information
mouse ... Parp1(11545)
Looking for similar products? Visit Product Comparison Guide
Application
3-Aminobenzamide has been used as a poly-(ADP-ribose) polymerase (PARP) inhibitor in various experimental studies.
Biochem/physiol Actions
3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
![[3aR-[2(3′aR*,8′aS*),3′aβ,8′aβ]]-(+)-2,2′-Methylenebis[3a,8a-dihydro-8H-indeno[1,2-d]oxazole] 98%](/deepweb/assets/sigmaaldrich/product/structures/134/031/294d2464-1571-4514-8e4c-c0cda1c1df7b/640/294d2464-1571-4514-8e4c-c0cda1c1df7b.png)
An improved nonisotopic test to screen a large series of new inhibitor molecules of poly (ADP-ribose) polymerase activity for therapeutic applications
Decker P, et al.
Clinical Cancer Research, 5(5), 1169-1172 (1999)
Poly (ADP-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm
OzduLger A, et al.
Pharmacological Research, 46(1), 67-73 (2002)
Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase
Zingarelli B, et al.
Cardiovascular Research, 36(2), 205-215 (1997)
Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation
Cuzzocrea S, et al.
European Journal of Pharmacology, 342(1), 67-76 (1998)
M L Kuo et al.
Biochemical and biophysical research communications, 219(2), 502-508 (1996-02-15)
Previous studies have shown that chemically generated nitric oxide (NO) can induce human leukemia HL-60 cells to undergo monocytic differentiation. We show here that exposure of HL-60 cells to chemical NO generators induces cell death via apoptosis which was examined
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service