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Key Documents

300M-1

Sigma-Aldrich

Cytokeratin (OSCAR) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

OSCAR, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (300M-14)
vial of 0.5 mL concentrate (300M-15)
bottle of 1.0 mL predilute (300M-17)
vial of 1.0 mL concentrate (300M-16)
bottle of 7.0 mL predilute (300M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG2a

control

prostate

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT1(3848)

General description

Anti-cytokeratin (OSCAR) is well-suited to distinguish epithelial carcinoma from non-epithelial malignancies and is used to aid epithelial tumor classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.

Quality


IVD
IVD
IVD
RUO

Linkage

Cytokeratin (OSCAR) Positive Control Slides , Product No. 300S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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F Sato et al.
The British journal of surgery, 88(3), 426-432 (2001-03-22)
The purpose of this study was to investigate whether the presence of lymph node micrometastasis in pathological lymph node-negative (pN0) oesophageal squamous cell carcinoma had prognostic value. Some 1840 lymph nodes were obtained from 50 patients with pN0 oesophageal squamous
OSCAR, a novel broad anti-cytokeratin antibody optimized for diagnostic immunohistochemistry
Gown, AM, Yaziji H, Barry TS, Hwang HC
United States and Canadian Academy of Pathology Annual Meeting, 2003 null
J E Lewis et al.
Human pathology, 28(6), 664-673 (1997-06-01)
Spindle cell carcinoma (SpCC) is uncommon, with a predilection for the upper aerodigestive tract. Its histogenesis has not been resolved, although most authors support the sarcomatoid carcinoma concept. Ploidy analysis and proliferation indices have not been reported for laryngeal SpCCs.
J D Mueller et al.
Cancer, 89(9), 1874-1882 (2000-11-07)
Tumor involvement of regional lymph nodes has a crucial impact on the prognosis of patients with adenocarcinoma of the esophagogastric junction (AEG). Although additional tumor cell deposits can be detected by sensitive methods (e.g., immunohistochemistry and polymerase chain reaction), their
A C Knapp et al.
Cell, 59(1), 67-79 (1989-10-06)
Intermediate filaments (IFs) of the cytokeratin (CK) type are cytoskeletal elements typical for epithelial differentiation. However, in diverse transformed culture lines of non-epithelial origin, rare cells emerge spontaneously, which synthesize, in addition to their vimentin IFs, CKs 8 and 18.
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