695068

Hydrofluoric acid

ACS reagent, 48%

• Synonym(s): HF
• Empirical Formula (Hill Notation): HF
• CAS Number: 7664-39-3
• Molecular Weight: 20.01
• EC Number: 231-634-8
• MDL number: MFCD00011346
• UNSPSC Code: 12352106
• PubChem Substance ID: 329761712
• NACRES: NA.21

Properties

• grade: ACS reagent
• vapor density: 1.27 (vs air)
• vapor pressure: 25 mmHg ( 20 °C)
• Assay: 48%
• form: liquid
• density: 1.15 g/mL at 25 °C (lit.)
• anion traces: chloride (Cl^-): ≤5 ppm; phosphate (PO₄^3-): ≤1 ppm; sulfate, sulfite (as SO₄^2-): ≤5 ppm
• cation traces: As: ≤0.05 ppm; Cu: ≤0.1 ppm; Fe: ≤1 ppm; heavy metals (as Pb): ≤0.5 ppm
• SMILES string: [H+].[F-]
• InChI: 1S/FH/h1H
• InChI key: KRHYYFGTRYWZRS-UHFFFAOYSA-N

Description

General description

Hydrofluoric acid is a solution of hydrogen fluoride (HF) in water. It is composed of hydrogen and fluoride. Hydrofluoric acid is a colorless and highly corrosive liquid. It is commonly used in the manufacture of hydrocarbons and polishing and conditioning glass. Additionally, it is used as a catalyst and in the synthesis of fluoride-containing compounds, and semiconductors.

Application

Hydrofluoric acid solution can be used as a reagent to synthesize:

• Cyanohydrin alkyl ethers via chiral Bronsted acid-mediated hydrocyanation of vinyl ethers with silyl cyanides.
• N, N-Dimethylaniline hydrochloride salts via Pd-catalyzed Buchwald-Hartwig amination of aryl triflates with dimethylamines.

It can also be used as a catalyst for the amidation of carboxylic acids with amines to synthesize amides.

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330,H314
• Precautionary Statements: P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable