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C5149

Sigma-Aldrich

Calcium Ionophore A23187 mixed calcium magnesium salt

Approximate 1:1 molar ratio Ca:Mg. Actual content given on label.

Synonym(s):

Calcimycin, Calcium Ionophore mixed calcium magnesium salt

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About This Item

Empirical Formula (Hill Notation):
C29H37N3O6
Molecular Weight:
523.62
MDL number:
MFCD00213962
UNSPSC Code:
12171500
PubChem Substance ID:
24892759
NACRES:
NA.47

Quality Level

200

Assay

99% (TLC)

form

powder

solubility

chloroform/methanol: 10 mg/mL, clear, faintly yellow

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

[Mg++].[Ca++].CNc1ccc2oc(CC3OC4(CCC3C)OC(C(C)CC4C)C(C)C(=O)c5ccc[nH]5)nc2c1C(O)=O

InChI

1S/C29H37N3O6.Ca.Mg/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;;/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);;/q;2*+2

InChI key

HKVXGTQLKZNXPV-UHFFFAOYSA-N

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Application

Calcium Ionophore A23187 mixed calcium magnesium salt has been used as a calcium ionophore to increase the intracellular levels of calcium.
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not to quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
078M4053V
047M4011V
14160914
14160914
064M4150V

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