Skip to Content
Merck
All Photos(2)

Key Documents

89458

Supelco

Aphidicolin

analytical standard

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C20H34O4
CAS Number:
Molecular Weight:
338.48
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥95% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]3C[C@@H]4C[C@]23CC[C@]4(O)CO

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChI key

NOFOAYPPHIUXJR-APNQCZIXSA-N

General description

Aphidicolin is a diterpenoid metabolite of the fungi, Cephalosporium aphidicola and Phoma betae. It is known to be an antiviral drug and inhibits the incorporation of thymidine into DNA of cultured human embryonic lung cells.

Application

Aphidicolin may be used as a reference standard in the determination of the analyte in plasma samples using gas chromatography coupled with mass spectrometry (GC-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A gas chromatographic mass spectrometric assay for the determination of aphidicolin in plasma of cancer patients.
Journal of Pharmaceutical Sciences, 78(5), 399-401 (1989)
Chemistry of Fungi (2008)
Aphidicolin: A specific inhibitor of DNA polymerases in the cytosol of rat liver.
Ohashi M, et al.
Biochemical and Biophysical Research Communications, 82(4), 1084-1090 (1978)
Devin Sok et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(49), 17624-17629 (2014-11-26)
Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored candidates for vaccine design and immunotherapy because of their great neutralization breadth and potency. However, methods of isolating bnAbs against this site have been limited by the
Julian H Elliott et al.
PLoS pathogens, 10(10), e1004473-e1004473 (2014-11-14)
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintaining HIV latency and histone deacetylase inhibitors (HDACi) may reverse latency by activating HIV

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service