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21223

Sigma-Aldrich

Hydroxyapatite

purum p.a., ≥90% (as Ca3(PO4)2, KT)

Synonym(s):

Calcium phosphate hydroxide, Durapatite, Hydroxylapatite

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About This Item

Linear Formula:
3Ca3(PO4)2 · Ca(OH)2
CAS Number:
1306-06-5
Molecular Weight:
502.31
EC Number:
215-145-7
MDL number:
MFCD00010904
UNSPSC Code:
12352300
PubChem Substance ID:
57647915
NACRES:
NA.21

grade

purum p.a.

Quality Level

100

Assay

≥90% (as Ca3(PO4)2, KT)

form

powder

impurities

≤5% water (KFT)

loss

≤10% loss on ignition, 800 °C

anion traces

chloride (Cl-): ≤500 mg/kg
sulfate (SO42-): ≤2000 mg/kg

cation traces

Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cu: ≤20 mg/kg
Fe: ≤400 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤10 mg/kg

SMILES string

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

InChI key

XYJRXVWERLGGKC-UHFFFAOYSA-D

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General description

Bone and tooth implant materials have been prepared from polycrystalline hydroxyapatite. The compressive, flexural, torsional and dynamic torsional strengths of polycrystalline hydroxyapatite were investigated. Electrophoretic deposition of hydroxyapatite on to flat titanium plate material has been studied.
Hydroxyapatite is a bioceramic mainly found in minerals of bone and teeth. Due to its high biocompatibility and similarity with inorganic components found in hard tissues, it is mainly used to produce biocomposites and prostheses for bones and teeth replacement.

Application

Hydroxyapatite may be used in the preparation of bioceramic specimens by incorporation of a small amount of silicon (0.4wt%) into the structure of hydroxyapatite. It may be used for the preparation of porous microstructures, having important prosthetic applications.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1305
BCCF8126
BCCF1046
BCCC5175
BCCB4445

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Hydroxyapatite synthesis and the benefits of its blend with calcium aluminate cement.
Oliveira IR, et al.
Ceramics International, 42(2), 2542-2549 (2016)
P Ducheyne et al.
Biomaterials, 7(2), 97-103 (1986-03-01)
Hydroxyapatite from two sources was electrophoretically deposited onto flat titanium plate material. Depending upon the deposition conditions various changes in the structure of the ceramic were identified. A well-adhering Ti-P compound was present at the interface. Hydroxyapatite oxygenated to various
Chemical characterization of silicon-substituted hydroxyapatite
Gibson I, et al.
Journal of Biomedical Materials Research, 44(4), 422-428 (1999)
Mechanical properties of sintered hydroxyapatite for prosthetic applications.
Akao M ,et al.
J. Mater. Sci., 16(3), 809-812 (1981)
Sergio Bertazzo et al.
Nature materials, 12(6), 576-583 (2013-04-23)
The accumulation of calcified material in cardiovascular tissue is thought to involve cytochemical, extracellular matrix and systemic signals; however, its precise composition and nanoscale architecture remain largely unexplored. Using nano-analytical electron microscopy techniques, we examined valves, aortae and coronary arteries
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