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8.52360

Sigma-Aldrich

Fmoc-L-propargylglycine

Novabiochem®

Synonym(s):

Fmoc-L-propargylglycine, N-Fluorenemethoxycarbonyl-L-propargyl glycine

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About This Item

Empirical Formula (Hill Notation):
C20H17NO4
CAS Number:
Molecular Weight:
335.35
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22

Pricing and availability is not currently available.

Quality Level

product line

Novabiochem®

form

solid

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

alkyne

storage temp.

15-25°C

SMILES string

N([C@@H](CC#C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C20H17NO4/c1-2-7-18(19(22)23)21-20(24)25-12-17-15-10-5-3-8-13(15)14-9-4-6-11-16(14)17/h1,3-6,8-11,17-18H,7,12H2,(H,21,24)(H,22,23)/t18-/m0/s1

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This Item
SAB4500514SAB1300948SAB4500509
species reactivity

human, mouse, rat

species reactivity

mouse, human, rat

species reactivity

human

species reactivity

mouse, human, rat

clone

1AD9, monoclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

rabbit

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

UniProt accession no.

P68400

UniProt accession no.

P68400

UniProt accession no.

Q8N752

UniProt accession no.

P48729

General description

Building block for the introduction by Fmoc SPPS of an amino acid bearing an alkyne side chain. Such derivatives are useful tools for the synthesis of cyclic peptides by an alkyne-alkyne Glaser coupling, involving Cu(OAc)2/pyridine and heating to 60 °C using microwaves.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Optical rotation α 25/D (c=1 in DMF): -21.0 - -18.0 °
Solubility (1 mmole in 2 ml DMF): clearly soluble

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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