554718

REV-ERBα Antagonist, SR8278

The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.

• Synonym(s): REV-ERBα Antagonist, SR8278, SR8278SR 8278
• Empirical Formula (Hill Notation): C₁₈H₁₉NO₃S₂
• CAS Number: 101910-24-1
• Molecular Weight: 361.48
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: >95% (HPLC)
• form: gum; solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to yellow-brown
• solubility: DMSO: 25 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC₅₀ = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC₅₀ = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

Other Notes

Kojetin, D., et al. 2010, Chem Bio in press

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable