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Key Documents

07-337

Sigma-Aldrich

Anti-SOS1 Antibody, CT

Upstate®, from rabbit

Synonym(s):

Anti-Anti-GF1, Anti-Anti-GGF1, Anti-Anti-GINGF, Anti-Anti-HGF, Anti-Anti-NS4, Anti-Anti-SOS-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_005633

UniProt accession no.

Q07889

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SOS1(6654)

Specificity

SOS1

Immunogen

peptide corresponding to amino acids 1243-1258 (KKSDHGNAFFPNSPSP) of murine Son of Sevenless Homolog 1 Protein (SOS 1)

Application

Anti-SOS1 Antibody, CT is an antibody against SOS1 for use in IP & WB.
Research Category
Signaling
Research Sub Category
MAP Kinases

Quality

routinely evaluated by immunoblot on 3T3/A31, A431 cell lysates, or HeLa nuclear extracts

Target description

175 kDa

Physical form

Format: Purified
Protein A chromatography
Protein A purified Rabbit Ig in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells.
Heather L Watt,Geetanjali D Kharmate,Ujendra Kumar
Cellular Signalling null
J Ng et al.
The Journal of biological chemistry, 272(39), 24542-24549 (1997-09-26)
Interleukin 2 (IL-2) induces tyrosine phosphorylation of STATs 3 and 5 (signal transducer and activator of transcription). We now show that IL-2 regulation of STAT3 proteins in T cells is a complex response involving activation of two forms of STAT3:
T cell receptor-induced phosphorylation of Sos requires activity of CD45, Lck, and protein kinase C, but not ERK.
Zhao, H, et al.
The Journal of Biological Chemistry, 272, 21625-21634 (1997)
Michael Bordonaro et al.
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Although neoplastic cells exhibit relatively higher sensitivity to hyperthermia than normal cells, hyperthermia has had variable success as an anti-cancer therapy. This variable outcome might be due to the fact that cancer cells themselves have differential degrees of sensitivity to

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