M9653

Methoxyacetyl chloride

97%

• Synonym(s): 2-methoxyacetyl chloride, Methoxyacetic acid chloride
• Linear Formula: CH₃OCH₂COCl
• CAS Number: 38870-89-2
• Molecular Weight: 108.52
• Beilstein: 1740244
• EC Number: 254-169-2
• MDL number: MFCD00000728
• UNSPSC Code: 12352100
• PubChem Substance ID: 24897347
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• form: liquid
• refractive index: n20/D 1.419 (lit.)
• bp: 112-113 °C (lit.)
• density: 1.187 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: COCC(Cl)=O
• InChI: 1S/C3H5ClO2/c1-6-2-3(4)5/h2H2,1H3
• InChI key: JJKWHOSQTYYFAE-UHFFFAOYSA-N

Description

Application

Methoxyacetyl chloride can be used for methoxyacetylation of:

• Bilocularin A to synthesize 8-Methoxyacetoxybilocularin A.
• Substituted and unsubstituted benzamides to synthesize N-(2-methoxyacetyl)-benzamides.

It can also be used for the synthesis of β-lactams by reacting with imines. and in the post-synthetic modification of the metal-organic framework (MOF), MIL-101, to synthesize a catalyst for cycloaddition reaction of CO₂ with propylene oxide.

Safety Information

• Pictograms: GHS02,GHS05,GHS06
• Signal Word: Danger
• Hazard Statements: H226 - H314 - H331 - H335
• Precautionary Statements: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 82.4 °F
• Flash Point(C): 28 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves