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909858

Sigma-Aldrich

Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA average Mn 20,000, lactide:glycolide 50:50

Synonym(s):

COOH-PEG-PLGA, Carboxylic acid PEG-PLGA

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About This Item

Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nC2H3O2
UNSPSC Code:
12352106
NACRES:
NA.23

form

powder or chunks

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 5,000 (by NMR)
PLGA average Mn 20,000 (by NMR)

color

white to tan

storage temp.

−20°C

Application

Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
Jijin Gu et al.
Molecular pharmaceutics, 12(8), 2889-2903 (2015-06-24)
The goal of this study was to develop and characterize a novel intravaginal film platform for targeted delivery of small interfering RNA (siRNA)-loaded nanoparticles (NP) to dendritic cells as a potential gene therapy for the prevention of sexually transmitted human
Soroush Ardekani et al.
Scientific reports, 5, 16258-16258 (2015-11-21)
Nitroglycerin (NTG) markedly enhances nitric oxide (NO) bioavailability. However, its ability to mimic the anti-inflammatory properties of NO remains unknown. Here, we examined whether NTG can suppress endothelial cell (EC) activation during inflammation and developed NTG nanoformulation to simultaneously amplify

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