1134357

Cisplatin

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): cis-Diammineplatinum(II) dichloride, cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin
• Linear Formula: Pt(NH₃)₂Cl₂
• CAS Number: 15663-27-1
• Molecular Weight: 300.05
• MDL number: MFCD00011623
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749409
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: cisplatin
• manufacturer/tradename: USP
• mp: 270 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: N.N.Cl[Pt]Cl
• InChI: 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
• InChI key: LXZZYRPGZAFOLE-UHFFFAOYSA-L

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cisplatin USP reference standard for use in specified quality tests and assays.

Also used to prepare standard and system suitability solution for assay and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):

• Cisplatin
• Cisplatin for Injection
• Carboplatin Injection

Biochem/physiol Actions

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300 - H315 - H317 - H319 - H334 - H335 - H350
• Precautionary Statements: P201 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable