PHL83333

Decursin

phyproof^® Reference Substance

• Synonym(s): (+)-Decursin, (7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate, 3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester
• Empirical Formula (Hill Notation): C₁₉H₂₀O₅
• CAS Number: 5928-25-6
• Molecular Weight: 328.36
• MDL number: MFCD00272154

Properties

• grade: primary reference standard
• product line: phyproof^® Reference Substance
• Assay: ≥90.0%
• manufacturer/tradename: PhytoLab
• application(s): food and beverages; pharmaceutical
• storage temp.: 2-8°C
• InChI: 1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
• InChI key: CUKSFECWKQBVED-INIZCTEOSA-N

Description

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG