SRP0305
HDAC/SIRT Substrate 1, fluorogenic
≥90% (HPLC)
Synonym(s):
HDAC, histone deacetylase
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
Assay
≥90% (HPLC)
form
aqueous solution
packaging
pkg of 500 nmol
shipped in
dry ice
storage temp.
−70°C
General description
A fluorogenic, acetylated peptide substrate for HDAC′s. Based on residues 379-382 of p53, Arg-His-Lys-Lys, Ac, a site of regulatory acetylation by the p300 and CBP acetyltransferases, lysines 381, 382, 1-3, it is a suitable substrate for HDAC2, HDAC3, and HDAC6 tested so far.
Application
Study enzyme kinetics, and screen small molecule inhibitors for drug discovery and HTS applications.
Physical form
Supplied as a 5 mM solution in DMSO.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
188.6 °F - closed cup
Flash Point(C)
87 °C - closed cup
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