SML3635
AGX51
≥98% (HPLC)
Synonym(s):
AGX 51, AGX-51, N-[3-(1,3-Benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-(phenylmethyl)propenamide, N-[3-(1,3-Benzodioxol-5-yl)-3-(2-methoxyphenyl)propyl]-N-benzylpropanamide
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About This Item
Empirical Formula (Hill Notation):
C27H29NO4
CAS Number:
Molecular Weight:
431.52
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Biochem/physiol Actions
AGX51 is an antagonist that blocks transcriptional regulators ID1-4 from binding basic helix-loop-helix (bHLH) transcription factor E47, causing ubiquitin-mediated degradation of IDs (10-40 μM for 2-48h; HCT116). AGX51 reduces cell viability, G0/G1 growth arrest, and a reduction in cyclin D1 levels in cultures (5-40 μM for 4-24h; HUVEC and HCT116) and suppresses ocular neovascularization in mouse models of age-related macular degeneration (AMD) and retinopathy of prematurity (ROP) in vivo (500 μg/mouse via twice daily i.p. or 1-30 μg/eye via intravitreal injection immediately and 7 days after rupture of Bruch’s membrane).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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