SAB5701796

Anti-Phospho-ULK1-S555 antibody produced in rabbit

• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• Quality Level: 100
• antibody product type: primary antibodies
• clone: polyclonal
• form: liquid
• species reactivity: human, rat, mouse
• concentration: 2.81 mg/mL
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: O75385
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer555)
• Gene Information: human ... ULk1(8408)

Description

General description

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Immunogen

A synthetic phosphorylated peptide around S555 of human Phospho-ULK1-S555 (NP_003556.1).

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable