species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 81.92-20000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL1F7(27178)
General description
The IL1F7 ELISA kit provides for the quantitative measurement of IL-37 in cell culture supernatants, plasma and serum.
The interleukin 37 (IL1F7) gene is expressed in several tissues such as thymus, lymph nodes, testis, uterus, placenta, bone marrow and lungs. The gene IL1F7 exists in five isoforms IL1F7a-e. The IL1F7 gene is mapped to human chromosome 2q14.1.
The interleukin 37 (IL1F7) gene is expressed in several tissues such as thymus, lymph nodes, testis, uterus, placenta, bone marrow and lungs. The gene IL1F7 exists in five isoforms IL1F7a-e. The IL1F7 gene is mapped to human chromosome 2q14.1.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Interleukin 37 (IL1F7) suppresses the innate immune response. The IL1F7 gene expression is associated with many inflammatory disorders including dermatosis, hepatopathy, digestive system disorders, autoimmune diseases, ischemia/reperfusion injury and other metabolic diseases. The anti-inflammatory action of IL1F7 might affect tumor inflammation mechanism.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Associations of the Interleukin?1 Gene Locus Polymorphisms with Risk to Hip and Knee Osteoarthritis: Gender and Subpopulation Differences.
Kaarvatn M H, et al.
Human immunology, 77(2), 151-161 (2013)
Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma.
Lin L, et al.
Scientific Reports, 6, 26757-26757 (2016)
Javier Rodríguez-Carrio et al.
Frontiers in immunology, 9, 2351-2351 (2018-10-30)
Introduction: B-cell activation is pivotal in rheumatoid arthritis (RA) pathogenesis and represents a relevant therapeutic target. The main aim of this study was to characterize the profiles of B-cell factors and their decoy receptors in RA and evaluate their clinical
The effects of selective hematopoietic expression of human IL-37 on systemic inflammation and atherosclerosis in LDLr-deficient mice.
Hoeke G, et al.
International Journal of Molecular Sciences, 18(8), 1672-1672 (2017)
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