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P0233

Sigma-Aldrich

Anti-Potassium Channel Kv4.2 (Shal1; RK5; Kcnd2) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
MFCD02097222
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat, human

technique(s)

western blot (chemiluminescent): 1:200-1:300

UniProt accession no.

Q9NZV8

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCND2(3751)
rat ... Kcnd2(65180)

Specificity

Recognizes full-length Kv4.2 protein.

Immunogen

synthetic peptide corresponding to amino acids 454-469 of rat potassium channel Kv4.2 (with additional N-terminal cysteine). The epitope is identical in human and highly homologous in mouse.

Physical form

Lyophilized at ~0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H312 + H332 - H412

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alicia M Hall et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(15), 6221-6230 (2015-04-17)
Neuronal hyperexcitability occurs early in the pathogenesis of Alzheimer's disease (AD) and contributes to network dysfunction in AD patients. In other disorders with neuronal hyperexcitability, dysfunction in the dendrites often contributes, but dendritic excitability has not been directly examined in
S L Roberds et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(5), 1798-1802 (1991-03-01)
Five distinct K+ channel cDNA molecules (RK1 to RK5) were cloned from either rat heart or rat aorta cDNA libraries. Four of the channels, RK1 to RK4, are similar or identical to Shaker-like K+ channels previously identified in rat brain
T J Baldwin et al.
Neuron, 7(3), 471-483 (1991-09-01)
A cDNA clone encoding a K+ channel polypeptide with 72% amino acid sequence identity to Drosophila Shal was isolated from rat hippocampus. Functional expression of the cDNA in Xenopus oocytes generated 4-amino-pyridine-sensitive K+ channels displaying rapid inactivation kinetics. The fastest
Jia-Hua Hu et al.
Nature communications, 11(1), 1567-1567 (2020-03-29)
Voltage-gated K+ channels function in macromolecular complexes with accessory subunits to regulate brain function. Here, we describe a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)-dependent mechanism that regulates the association of the A-type K+ channel subunit Kv4.2 with its auxiliary subunit

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