L4129
L-α-Lysophosphatidylcholine from egg yolk
≥99%, Type I, powder
Synonym(s):
1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
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About This Item
Recommended Products
biological source
egg yolk
Quality Level
description
zwitterionic
type
Type I
Assay
≥99%
form
powder
color
white
functional group
phospholipid
lipid type
phosphoglycerides
shipped in
ambient
storage temp.
−20°C
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Application
L-α-Lysophosphatidylcholine from egg yolk has been used:
- as a surfactant
- as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
- as a demyelinating agent for nerve
- as a component in sperm nuclei preparation buffer
Biochem/physiol Actions
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.
Quality
Contains primarily palmitic and stearic acids.
Preparation Note
Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress toward therapies that modulate the microbiota with the aim of limiting immune-mediated demyelination
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