I4269
Interleukin-4 human
IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
IL-4, hIL-4
About This Item
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
≤0.400 ng/mL EC50
quality
endotoxin tested
mol wt
14.9 kDa (containing 129 amino acid residues)
packaging
pkg of 5 and 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
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General description
IL-4 binds to two distinct receptors; the type I receptor, a heterodimer consisting of the IL-4Rα chain and the common gamma chain, γc, and the type II receptor, a heterodimer of IL-4Rα and IL-13Rα1.4
Naturally occurring IL-4 has a molecular mass of 12-20 kDa. Recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues. Human and mouse IL-4 share a 50% amino acid sequence homology, but their biological actions are species-specific.5
Application
Physical form
Analysis Note
Citation
2. O′Garra, A., and Arai, N., The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol., 10, 542-550 (2000).
3. Ryan, J.J. et al., Mast cell homeostasis: a fundamental aspect of allergic disease. Crit. Rev. Immunol., 27, 15-32 (2007).
4. Callard, R.E. et al., IL-4 and IL-13 receptors: are they one and the same? Immunol. Today, 17, 108-110 (1996).
5. Yokota, T. et al., Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol. Rev., 102, 137-187 (1988).
6. Kitamura, T. et al., Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J. Cell Physiol., 140, 323-334 (1989).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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