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G0902

Sigma-Aldrich

Ginsenoside-Rc from Panax ginseng (Korean ginseng) root

triterpenoid saponin, ≥98% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C53H90O22
CAS Number:
11021-14-0
Molecular Weight:
1079.27
EC Number:
234-253-5
MDL number:
MFCD00133368
UNSPSC Code:
12352201
PubChem Substance ID:
24895029
NACRES:
NA.25

biological source

plant root (Panax ginseng)

Quality Level

200

Assay

≥98% (HPLC)

form

powder

technique(s)

HPLC: suitable

storage temp.

2-8°C

SMILES string

C\C(C)=C\CCC(C)(OC1OC(COC2OC(CO)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C

InChI

1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-68-45-41(65)36(60)28(21-56)69-45)24-11-16-52(7)33(24)25(57)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)35(59)27(20-55)71-48)74-46-42(66)38(62)34(58)26(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3

InChI key

JDCPEKQWFDWQLI-UHFFFAOYSA-N

Biochem/physiol Actions

Ginsenoside-Rc exhibits anti-proliferative effects on human breast cancer cell lines and can induce expreβion of the leucine-zipper transcription factor c-fos.
Triterpene saponin found in ginseng.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Louis Y Chan et al.
Reproductive toxicology (Elmsford, N.Y.), 19(1), 131-134 (2004-09-01)
Pregnant women commonly consume ginseng. However, there is little data concerning the effects of ginseng on early pregnancy. Rat embryos were exposed in vitro to different concentrations of Rc and Re from day 9.5 to day 11.5 after conception. Embryos
Myoung-Su Lee et al.
Journal of ethnopharmacology, 127(3), 771-776 (2009-12-08)
Panax ginseng and its major component, ginsenosides, are widely used for the prevention of various disorders in oriental medicine. To evaluate the effect of ginsenoside Rc (Rc), one of the active constituents in Panax ginseng, on glucose uptake in C2C12
Ron Luchtefeld et al.
Journal of agricultural and food chemistry, 52(16), 4953-4956 (2004-08-05)
A method based on high-performance liquid chromatography (HPLC) and negative ion electrospray mass spectrometry (LC-MS) has been used to determine ginsenosides Rb1, Rc, and Re in six different samples of ginseng. These included a liquid extract, capsules, tea bags, and
T B Ng et al.
Journal of ethnopharmacology, 16(2-3), 191-199 (1986-06-01)
Ginsenosides Rb2, Rc and Rg1 suppressed corticotropin-induced, dibutyryl cyclic AMP-induced and epinephrine-induced lipolysis with the relative potencies Rb2 greater than Rc greater than Rg1. The inhibition of corticotropin-induced lipolysis by ginsenoside Rg1 could not be overcome by increasing the dose
Young Joo Lee et al.
Archives of pharmacal research, 26(1), 53-57 (2003-02-06)
We have found that ginsenoside Rc and Re induce c-fos in MCF-7 human breast carcinoma cells at both the mRNA and protein levels. However, neither ginsenoside activated the expression of reporter gene under the control of AP-1/TPA response elements. We
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Chromatograms

application for HPLC

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