F5392
Fibroblast Growth Factor-Basic from bovine pituitary
FGF-Basic, suitable for cell culture
Synonym(s):
FGF2, bFGF
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About This Item
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biological source
bovine pituitary glands
Quality Level
Assay
~90% (SDS-PAGE and N-terminal analysis)
form
lyophilized powder
potency
0.03-3.0 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
16.4 kDa
packaging
pkg of 1 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
<0.5 EU/vial
color
white
UniProt accession no.
storage temp.
−20°C
Gene Information
bovine ... FGF2(281161)
General description
The fibroblast growth factor-2 (FGF2) gene is predominantly expressed in uterus, cornea and vascular endothelial cells. The FGF2 gene is mapped to cattle chromosome 17.
Application
A natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.
Fibroblast Growth Factor-Basic from bovine pituitary has been used:
Fibroblast Growth Factor-Basic from bovine pituitary has been used:
- In animal and human cell culture
- In neuronal induction of adipose and bone marrow-derived rat mesenchymal stem cells
- In the generation of directly reprogramming fibroblast
- In human glioma cell culture
Biochem/physiol Actions
Fibroblast growth factor-2 (FGF2) stimulates cell proliferation, differentiation and migration. It is also known to participate in angiogenesis and carcinogenesis. During the estrous cycle, FGF2 expression is found to be maximum in porcine conceptuses and endometrium. Upregulation of this gene is also observed in pregnancy during peri-implantation. FGF2 is involved in embryogenesis, tissue repair and other metabolic pathways.
Physical form
Lyophilized from a 0.2 μm filtered solution in sodium phosphate and sodium chloride containing 0.1 mg bovine serum albumin
Preparation Note
Purified glands by a modification of the method of Gospodarowicz, et al.
Analysis Note
The proliferative activity is tested in culture using fetal bovine heart endothelial cells.
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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