E1283

ERK2, active, GST tagged human

recombinant, expressed in E. coli, PRECISIO^® Kinase, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(s): ERT1, MAPK1, MAPK2, P41mapk, P42MAPK, PRKM1, PRKM2, p40, p47
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• recombinant: expressed in E. coli
• Quality Level: 200
• product line: PRECISIO^® Kinase
• Assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 613-829 nmol/min·mg
• mol wt: ~68 kDa
• UniProt accession no.: P28482
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... MAPK1(5594)

Description

Biochem/physiol Actions

ERK2 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Activation of ERK2 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK2 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK2 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta).

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable