D4072

Delta Sleep Inducing Peptide

• Synonym(s): DSIP, Emideltide, Sleep inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
• Empirical Formula (Hill Notation): C₃₅H₄₈N₁₀O₁₅
• CAS Number: 62568-57-4
• Molecular Weight: 848.81
• MDL number: MFCD00076883
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798794
• NACRES: NA.32

Properties

• form: powder
• storage temp.: −20°C
• SMILES string: C[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C35H48N10O15/c1-16(41-32(56)20(36)9-18-11-37-21-6-4-3-5-19(18)21)30(54)39-12-25(47)38-13-26(48)44-23(10-29(52)53)34(58)42-17(2)31(55)45-24(15-46)33(57)40-14-27(49)43-22(35(59)60)7-8-28(50)51/h3-6,11,16-17,20,22-24,37,46H,7-10,12-15,36H2,1-2H3,(H,38,47)(H,39,54)(H,40,57)(H,41,56)(H,42,58)(H,43,49)(H,44,48)(H,45,55)(H,50,51)(H,52,53)(H,59,60)/t16-,17-,20-,22-,23-,24-/m0/s1
• InChI key: ZRZROXNBKJAOKB-GFVHOAGBSA-N

Description

Amino Acid Sequence

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH

General description

Delta sleep inducing peptide (DSIP) is a nonapeptide which was isolated from the rabbit brain. It is synthesized in the hypothalamus and is present in small amounts in the blood.

Biochem/physiol Actions

DSIP promotes sleep by targeting various areas of the brain. The peptide is easily absorbed from the gut and is not denatured by enzymes. It crosses the blood-brain barrier easily. DSIP influences the circadian rhythm in humans. Low concentrations of the peptide are observed in patients with schizophrenia and depression.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable