D1530

1α,25-Dihydroxyvitamin D₃

≥99% (HPLC)

• Synonym(s): 1α,25-Dihydroxycholecalciferol, Calcitriol
• Empirical Formula (Hill Notation): C₂₇H₄₄O₃
• CAS Number: 32222-06-3
• Molecular Weight: 416.64
• Beilstein: 7559394
• EC Number: 250-963-8
• MDL number: MFCD00867079
• UNSPSC Code: 12352205
• eCl@ss: 34058003
• PubChem Substance ID: 24893473
• NACRES: NA.79

Properties

• Quality Level: 300
• Assay: ≥99% (HPLC)
• form: solid
• technique(s): HPLC: suitable
• storage temp.: −20°C
• SMILES string: [H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O
• InChI: 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
• InChI key: GMRQFYUYWCNGIN-NKMMMXOESA-N
• Gene Information: human ... VDR(7421)

Description

Biochem/physiol Actions

Biologically active form of vitamin D₃ in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D₃ has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D₃ acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330,H372
• Precautionary Statements: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Hazard Classifications: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves