C7482
Caspase 6 human
recombinant, expressed in E. coli, >90% (SDS-PAGE), lyophilized powder, 13,000 units/mg protein
Synonym(s):
Mch2
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
recombinant
expressed in E. coli
Quality Level
Assay
>90% (SDS-PAGE)
form
lyophilized powder
specific activity
13,000 units/mg protein
mol wt
~30 kDa
solubility
PBS: soluble
shipped in
dry ice
storage temp.
−70°C
Biochem/physiol Actions
Cleaves the substrates consisting of consensus sequence VEID.
Spontaneously undergoes autoprocessing to yield the subunits associated to form the active enzyme.
Useful in screening caspase inhibitors, studying enzyme regulation, determining specificity of caspase substrates, or as a positive control in caspase activity assays.
Unit Definition
One unit will hydrolyze 1 nmol of the caspase substrate VEID-pNA to VEID and p-nitroaniline per hour at pH 7.2 at 37 °C.
Physical form
Contains 0.052% ammonium sulfate, 0.158% Tris−HCl, 0.76% sodium chloride.
Certificates of Analysis (COA)
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Ana A Baburamani et al.
Developmental neuroscience, 37(4-5), 321-337 (2015-04-01)
Apoptotic mechanisms are centre stage for the development of injury in the immature brain, and caspases have been shown to play a pivotal role during brain development and in response to injury. The inhibition of caspases using broad-spectrum agents such
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