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210R-1

Sigma-Aldrich

Prolactin (EP193) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP193, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (210R-17)
bottle of 7.0 mL predilute (210R-18)
vial of 0.1 mL concentrate (210R-14)
vial of 0.5 mL concentrate (210R-15)
vial of 1.0 mL concentrate (210R-16)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

General description

Prolactin (PRL) is a single-chain polypeptide of 226 amino acids with a molecular weight of about 24 kD. Prolactin plays a role in multiple processes including cell growth, reproduction, and immune function.1 The pituitary hormone PRL is involved in tumorigenesis in rodents and humans. PRL promotes proliferation, survival, and migration of cancer cells acting via the PRL receptor.5 Anti-prolactin is a useful marker in classification of pituitary tumors and the study of pituitary disease as it reacts with prolactin-producing cells.2-4 Such prolactin-producing cells can also be found in prostate epithelium.5

Quality


IVD
IVD
IVD
RUO

Linkage

Prolactin Positive Control Slides, Product No. 210S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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M T Nevalainen et al.
The Journal of clinical investigation, 99(4), 618-627 (1997-02-15)
Prolactin is widely expressed in different tissues, and it is presumed to have both local and systemic actions. In males it is known to influence reproductive functions but the significance and mechanisms of prolactin action in male accessory reproductive tissues
T M Duello et al.
The American journal of anatomy, 158(4), 463-469 (1980-08-01)
Among 92 surgically removed pituitary adenomas immunostained for prolactin and growth hormone, 70 showed positive staining for prolactin. The majority of these (54) was associated with hyperprolactinemia leading to amenorrhea (and often galactorrhea) in women of reproductive age. Similar tumors
A Popadić et al.
Surgical neurology, 51(1), 47-54 (1999-02-10)
Malignant prolactinomas are rare events. To date, only 14 patients with metastases in- or outside the central nervous system have been reported. We present a patient who developed a metastasis to the cauda equina, which is the first case documented
S L Asa et al.
Archives of pathology & laboratory medicine, 106(7), 360-363 (1982-07-01)
Sixty adult human pituitary glands taken at autopsy were stained for prolactin using the immunoperoxidase technique, and percentages of prolactin-bearing cells were assessed. There was no difference between the percentages of prolactin cells seen in the adenohypophyses of adult men
Giuseppe Minniti et al.
Surgical neurology, 57(2), 99-103 (2002-03-21)
Prolactinomas invading the skull base are rare, and could easily be confused with skull base tumors of nonpituitary origin. We report a series of 4 cases of giant prolactinomas invading the skull base and presenting with atypical symptoms. Case 1

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