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P0597

Pilocarpine nitrate

Name: Pilocarpine nitrate
Brand: SIAL

meets USP testing specifications

Synonym(s):

Pilocarpine nitrate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₆N₂O₂ · HNO₃

CAS Number:

148-72-1

Molecular Weight:

271.27

Beilstein:

4171406

EC Number:

205-723-7

MDL number:

MFCD00078497

UNSPSC Code:

12352200

PubChem Substance ID:

24898116

NACRES:

NA.21

Agency

USP/NF
meets USP testing specifications

Quality Level

200

form

crystals

application(s)

pharmaceutical (small molecule)

SMILES string

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

InChI key

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Gene Information

human ... CHRM1(1128) , CHRM3(1131)

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Biochem/physiol Actions

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Pictograms

GHS03,GHS06

Signal Word

Danger

Hazard Statements

H272 - H302 - H330

Precautionary Statements

P210 - P220 - P260 - P264 - P301 + P312 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Storage Class Code

5.1B - Oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice.

Olav B Smeland et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1090-1097 (2013-04-25)

Although certain metabolic characteristics such as interictal glucose hypometabolism are well established for temporal lobe epilepsy (TLE), its pathogenesis still remains unclear. Here, we performed a comprehensive study of brain metabolism in a mouse model of TLE, induced by pilocarpine-status

Changes in microRNA expression in the whole hippocampus and hippocampal synaptoneurosome fraction following pilocarpine induced status epilepticus.

Rashmi M Risbud et al.

PloS one, 8(1), e53464-e53464 (2013-01-12)

MicroRNAs regulate protein synthesis by binding non-translated regions of mRNAs and suppressing translation and/or increasing mRNA degradation. MicroRNAs play an important role in the nervous system including controlling synaptic plasticity. Their expression is altered in disease states including stroke, head

Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.

Georgette L Suidan et al.

Arteriosclerosis, thrombosis, and vascular biology, 33(9), 2112-2120 (2013-07-05)

Aberrant blood-brain barrier (BBB) permeability is a hallmark pathology of many central nervous system diseases. von Willebrand factor (VWF) is stored in endothelial Weibel-Palade bodies from where it is released on activation into plasma and basement membrane. The role of

Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy.

Linda Holtman et al.

Epilepsia, 54(4), 589-595 (2013-02-13)

Brain inflammation occurs during epileptogenesis and may contribute to the development and progression of temporal lobe epilepsy. Recently, several studies have indicated that seizures may also increase specific blood plasma cytokine levels in animal models as well as in human

High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy.

Kathleen Heng et al.

Epilepsia, 54(9), 1535-1541 (2013-07-16)

The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely

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