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ABS538

Sigma-Aldrich

Anti-FABP1 Antibody

serum, from rabbit

Synonym(s):

Fatty acid-binding protein, liver, Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, L-FABP, Squalene- and sterol-carrier protein, SCP, Z-protein, p14

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

species reactivity (predicted by homology)

rat (based on 100% sequence homology)

technique(s)

western blot: suitable

NCBI accession no.

NP_036688

UniProt accession no.

P02692

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

rat ... Fabp1(24360)

General description

FABP1, also known as Fatty acid-binding protein, Liver Fatty acid-binding protein, Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, L-FABP, Squalene- and sterol-carrier protein, SCP, Z-protein, or p14, and encoded by the gene FABP1/FABPL, is an important fatty acid binding and transport protein. FABP1 is produced in the liver and is part of a family of lipid carrier proteins. FABP1 facilitate the transfer of fatty acids between extra and intracellular membranes. FABP1 level in the blood is used as a biomarker for obesity and type II diabetes. Additionally, recent research indicates that FABP1 can modulate stellate cell activation and this may lead to diet-induced nonalcoholic fatty liver disease, thus FABP1 is a key focus of metabolic research.

Immunogen

Recombinant protein corresponding to rat FABP1.

Application

Anti-FABP1 Antibody detects level of FABP1 & has been published & validated for use in FABP1.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected FABP1 in wild type mouse liver cytosol and not in LFABP-1 -/- mouse liver cytosol.

Quality

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FABP1 in 10 µg of human liver tissue lysate.

Target description

~ 14 kDa observed

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol.
Lagakos, William S, et al.
The Journal of Biological Chemistry, 288, 19805-19815 (2013)
William Stacy Lagakos et al.
American journal of physiology. Gastrointestinal and liver physiology, 300(5), G803-G814 (2011-02-26)
It has long been known that mammalian enterocytes coexpress two members of the fatty acid-binding protein (FABP) family, the intestinal FABP (IFABP) and the liver FABP (LFABP). Both bind long-chain fatty acids and have similar though not identical distributions in

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