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LM1202

Avanti

17:0-20:4 PG

Avanti Research™ - A Croda Brand

Synonym(s):

1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1′-rac-glycerol) (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C43H80NO10P
CAS Number:
1246304-50-6
Molecular Weight:
802.07
UNSPSC Code:
12352211
NACRES:
NA.25

form

methanol solution

packaging

pkg of 1 × 1 mL (LM1202-1EA)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

~10 μg/mL (Refer to C of A for lot specific concentration.)

application(s)

lipidomics
metabolomics

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC(O)CO)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+]

General description

Phosphatidylglycerol (PG) is mostly found in the pulmonary surfactant and localized to the alveoli.

Application

17:0-20:4 PG or 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1′-rac-glycerol):
  • has been used as an internal standard (IS) in lipid extraction from isolated pure mitochondria for mass spectrometry (MS) analysis
  • has been used as an internal standard (IS) in liquid chromatography (LC)-MS analysis
  • might be used in dual substrate (acyl-CoA and lysophospholipid) choice acyltransferase assay
  • might be used for quantitative phospholipid analysis by MS

Biochem/physiol Actions

Phosphatidylglycerol (PG) is known to be involved in the inflammatory mechanism and offers protection against viral infection.

Packaging

2 mL Amber Glass Sealed Ampule (LM1202-1EA)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

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Christoph Potting et al.
Cell metabolism, 18(2), 287-295 (2013-08-13)
Cardiolipin (CL), a mitochondria-specific glycerophospholipid, is required for diverse mitochondrial processes and orchestrates the function of various death-inducing proteins during apoptosis. Here, we identify a complex of the p53-regulated protein TRIAP1 (p53CSV) and PRELI in the mitochondrial intermembrane space (IMS)
Milena Vukotic et al.
Molecular cell, 67(3), 471-483 (2017-07-18)
Mutations in mitochondrial acylglycerol kinase (AGK) cause Sengers syndrome, which is characterized by cataracts, hypertrophic cardiomyopathy, and skeletal myopathy. AGK generates phosphatidic acid and lysophosphatidic acid, bioactive phospholipids involved in lipid signaling and the regulation of tumor progression. However, the

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