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L134

Sigma-Aldrich

Linopirdine

≥98% (HPLC)

Synonym(s):

1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one, DuP 996

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About This Item

Empirical Formula (Hill Notation):
C26H21N3O
CAS Number:
105431-72-9
Molecular Weight:
391.46
MDL number:
MFCD00867216
UNSPSC Code:
12352100
PubChem Substance ID:
57654323
NACRES:
NA.22

Assay

≥98% (HPLC)

color

white to off-white

solubility

DMSO: >10 mg/mL
ethanol: 240 mg/mL

SMILES string

O=C1N(c2ccccc2)c3ccccc3C1(Cc4ccncc4)Cc5ccncc5

InChI

1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2

InChI key

YEJCDKJIEMIWRQ-UHFFFAOYSA-N

Gene Information

rat ... Kcnj1(24521)

General description

Linopiridine is a class of drugs that activates the nervous system and enhances the acetylcholine (Ach) in the brain. It can be prepared by reacting oxiindole with 4-picolyl chloride hydrochloride in the presence of a KF-Al2O3 catalyst.

Biochem/physiol Actions

Stimulates release of acetylcholine and other neurotransmitters; cognitive enhancer.

Legal Information

Sold under exclusive license from DuPont.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The M-current (current through Kv7 channels) is a low-threshold noninactivating potassium current that is suppressed by muscarinic agonists. Recent studies have shown its role in spike burst generation and intrinsic subthreshold theta resonance, both of which are important for memory
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(42), 13353-13364 (2009-10-23)
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