I9760
Iodoacetic acid N-hydroxysuccinimide ester
for peptide synthesis
Synonym(s):
N-Hydroxysuccinimide iodoacetate, N-Iodoacetoxysuccinimide
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About This Item
Empirical Formula (Hill Notation):
C6H6INO4
CAS Number:
Molecular Weight:
283.02
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
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product name
Iodoacetic acid N-hydroxysuccinimide ester, powder
form
powder
reaction suitability
reagent type: cross-linking reagent
solubility
DMF: 50 mg/mL
application(s)
peptide synthesis
functional group
NHS ester
storage temp.
−20°C
SMILES string
O=C(N1OC(CI)=O)CCC1=O
InChI
1S/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
InChI key
VRDGQQTWSGDXCU-UHFFFAOYSA-N
Application
A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) Second coupling specific for molecules containing free sulfydryl by thioether linkage buffered at pH 7.5 (7.0-8.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 2-atom linker.
Caution
The iodoacetyl group is light sensitive.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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