793841

2,2-Difluoroacetophenone

• Synonym(s): α,α-Difluoroacetophenone, 2,2-Difluoro-1-phenylethanone, Difluoromethyl phenyl ketone
• Empirical Formula (Hill Notation): C₈H₆F₂O
• CAS Number: 395-01-7
• Molecular Weight: 156.13
• MDL number: MFCD06246879
• UNSPSC Code: 12352101
• PubChem Substance ID: 329768421
• NACRES: NA.22

Properties

• form: liquid
• Quality Level: 100
• density: 1.180±0.06 g/mL
• functional group: fluoro; ketone; phenyl
• SMILES string: FC(F)C(C1=CC=CC=C1)=O
• InChI: 1S/C8H6F2O/c9-8(10)7(11)6-4-2-1-3-5-6/h1-5,8H
• InChI key: OLYKCPDTXVZOQF-UHFFFAOYSA-N

Description

Application

Product was reported by Hartwig and coworkers in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides.


Pd-Catalyzed a-Arylation of a;a-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 158.0 °F
• Flash Point(C): 70 °C