677213

(R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol trimethylsilyl ether

technical grade

• Synonym(s): (R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether, (R)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)]trimethylsilanyloxy)methyl]pyrrolidine, (R)-2-[(Bis(3,5-bis(trifluoromethyl)phenyl)]trimethylsilyloxy)methyl]pyrrolidine
• Empirical Formula (Hill Notation): C₂₄H₂₃F₁₂NOSi
• CAS Number: 908303-26-4
• Molecular Weight: 597.51
• MDL number: MFCD09750448
• UNSPSC Code: 12352005
• PubChem Substance ID: 24885357
• NACRES: NA.22

Properties

• grade: technical grade
• optical purity: enantiomeric excess: ≥99.0% (HPLC)
• mp: 46-55 °C
• functional group: fluoro
• SMILES string: C[Si](C)(C)OC([C@H]1CCCN1)(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3cc(cc(c3)C(F)(F)F)C(F)(F)F
• InChI: 1S/C24H23F12NOSi/c1-39(2,3)38-20(19-5-4-6-37-19,13-7-15(21(25,26)27)11-16(8-13)22(28,29)30)14-9-17(23(31,32)33)12-18(10-14)24(34,35)36/h7-12,19,37H,4-6H2,1-3H3/t19-/m1/s1
• InChI key: MOHRGTBNEJKFMB-LJQANCHMSA-N

Description

Application

Catalyst involved in:

• Cyclocondensation of enals with methylenepyrrolidines
• Organocatalytic additions of β-ketosulfoxides to conjugated aldehydes
• Organocatalytic aza-Michael reactions
• Stereoselective propargylic alkylation of propargylic esters with aldehydes
• Epoxidation or aziridination of α,β-unsaturated aldehydes and Feist-Benary reactions of 1,3-dicarbonyls

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): >230.0 °F - closed cup
• Flash Point(C): > 110 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves